| 15/12/20 17:00 | CA Pulpileno | CD Lugo | 1-2 |
| 15/12/20 18:00 | CD Marchamalo | SD Huesca | 2-3a.e.t |
| 15/12/20 18:00 | UD Tomares | CA Osasuna | 0-6 |
| 15/12/20 18:00 | CD Cantolagua | Real Valladolid | 0-5 |
| 15/12/20 18:00 | Sestao River Club | CD Teneriffa | 0-2a.e.t |
| 15/12/20 18:00 | Club Portugalete | SD Ponferradina | 1-0 |
| 15/12/20 19:00 | CF Lucena | FC Sevilla | 0-3 |
| 15/12/20 19:00 | CF Ourense | CD Leganes | 0-1a.e.t |
| 15/12/20 19:30 | CD Coria | Real Oviedo | 2-3 |
| 16/12/20 14:15 | FC Coruxo | FC Malaga | 0-4 |
| 16/12/20 14:30 | CD Lealtad de Villaviciosa | AD Alcorcon | 1-2 |
| 16/12/20 15:00 | Burgos CF | Andorra CF | 2-0 |
| 16/12/20 17:00 | CD Quintanar del Rey | Sporting Gijon | 1-2 |
| 16/12/20 17:00 | CE L'Hospitalet | UD Almeria | 1-4 |
| 16/12/20 17:00 | CD San Fernando | CD Castellon | 0-2 |
| 16/12/20 17:00 | Cordoba CF | Albacete Balompie | 1-0 |
| 16/12/20 17:30 | CD Numancia | Lorca Deportiva CF | 4-1 |
| 16/12/20 18:00 | Racing Murcia | UD Levante | 0-5 |
| 16/12/20 18:00 | CD Cardassar | Atletico Madrid | 0-3 |
| 16/12/20 18:00 | CF Terrassa | FC Valencia | 2-4a.e.t |
| 16/12/20 18:00 | Las Rozas CF | CD Mirandes | 1-0 |
| 16/12/20 18:00 | Gimnastica de Torrelavega | Real Saragossa | 0-2a.e.t |
| 16/12/20 18:00 | UE Llagostera | Espanyol Barcelona | 0-1a.e.t |
| 16/12/20 18:00 | CD Ibiza Islas Pitiusas | CD Sabadell | 0-2 |
| 16/12/20 18:00 | Atletico Baleares | CF Fuenlabrada | 0-1 |
| 16/12/20 18:00 | SD Amorebieta | UD Logrones | 1-0 |
| 16/12/20 18:00 | Sadcf Internacional De Madrid Dsl | Linares Deportivo | 0-3 |
| 16/12/20 18:30 | CD Guijuelo | RCD Mallorca | 0-1 |
| 16/12/20 18:30 | CF Rayo Majadahonda | Yeclano Deportivo | 1-2a.e.t |
| 16/12/20 19:00 | Marbella FC | Club Lleida Esportiu | 1-0a.e.t |
| 16/12/20 19:30 | CD Calahorra | CF La Nucia | 0-1 |
| 16/12/20 20:00 | CD Bunol | FC Elche | 1-2 |
| 16/12/20 20:00 | CD Rincon | Deportivo Alaves | 0-2 |
| 16/12/20 20:00 | SD Leioa | FC Villarreal | 0-6 |
| 16/12/20 22:30 | CD Marino | UE Cornella | 0-1 |
| 17/12/20 16:00 | Deportivo La Coruna | CD El Ejido | 1-0 |
| 17/12/20 17:00 | CD Artistico Navalcarnero | CD Badajoz | 1-0 |
| 17/12/20 18:00 | CD Anaitasuna | FC Getafe | 1-2 |
| 17/12/20 18:00 | CD Ribadumia | FC Cadiz | 0-2 |
| 17/12/20 18:00 | AD San Juan | FC Granada | 0-2 |
| 17/12/20 18:00 | Gimnastica Segoviana | FC Girona | 0-2 |
| 17/12/20 18:00 | CD Teruel | Rayo Vallecano | 2-3a.e.t |
| 17/12/20 18:00 | UD Ibiza Eivissa | SD Compostela | 2-1a.e.t |
| 17/12/20 18:00 | Cultural y Deportiva Leonesa | CF Villanovense | 1-0 |
| 17/12/20 18:00 | Union Mutilvera | Racing Santander | 1-0 |
| 17/12/20 18:30 | UCAM Murcia | Real Betis Sevilla | 0-2 |
| 17/12/20 18:30 | Deportiva Santa Eulalia del Rio | SD Tarazona | 4-1 |
| 17/12/20 19:00 | CD Varea | UD Las Palmas | 0-4 |
| 17/12/20 19:00 | CF Pontevedra | FC Cartagena | 2-1 |
| 17/12/20 19:15 | CD Alcoyano | CD Laredo | 4-1 |
| 17/12/20 19:30 | UD Extremadura | UD Socuellamos | 1-2 |
| 17/12/20 20:00 | Racing Rioja | SD Eibar | 0-2 |
| 17/12/20 20:00 | UD Llanera | Celta Vigo | 0-5 |
| 23/12/20 17:30 | Club Haro Deportivo | Linense | 2-1 |
| 23/12/20 18:00 | Zamora CF | SD Logrones | 2-1 |
| 30/12/20 11:00 | UD Poblense | Olot | 1-2 |
