| Date | Home | Away | Result |
|---|---|---|---|
| 16/09/22 19:30 | FSV Mainz 05 | Hertha BSC | 1-1 |
| 17/09/22 14:30 | VfB Stuttgart | Eintracht Frankfurt | 1-3 |
| 17/09/22 14:30 | FC Augsburg | FC Bayern Munich | 1-0 |
| 17/09/22 14:30 | Bayer 04 Leverkusen | Werder Bremen | 1-1 |
| 17/09/22 14:30 | Borussia Dortmund | FC Schalke 04 | 1-0 |
| 17/09/22 17:30 | Bor. Mönchengladbach | RB Leipzig | 3-0 |
| 18/09/22 14:30 | 1. FC Union Berlin | VfL Wolfsburg | 2-0 |
| 18/09/22 16:30 | VfL Bochum | 1. FC Köln | 1-1 |
| 18/09/22 18:30 | 1899 Hoffenheim | SC Freiburg | 0-0 |