| Date | Home | Away | Result |
|---|---|---|---|
| 06/05/22 19:30 | VfL Bochum | Arminia Bielefeld | 2-1 |
| 07/05/22 14:30 | 1899 Hoffenheim | Bayer 04 Leverkusen | 2-4 |
| 07/05/22 14:30 | SC Freiburg | 1. FC Union Berlin | 1-4 |
| 07/05/22 14:30 | SpVgg Greuther Fürth | Borussia Dortmund | 1-3 |
| 07/05/22 14:30 | 1. FC Köln | VfL Wolfsburg | 0-1 |
| 07/05/22 17:30 | Hertha BSC | FSV Mainz 05 | 1-2 |
| 08/05/22 14:30 | Eintracht Frankfurt | Bor. Mönchengladbach | 1-1 |
| 08/05/22 16:30 | FC Bayern Munich | VfB Stuttgart | 2-2 |
| 08/05/22 18:30 | RB Leipzig | FC Augsburg | 4-0 |