| Date | Home | Away | Result |
|---|---|---|---|
| 22/04/22 19:30 | VfL Wolfsburg | FSV Mainz 05 | 5-0 |
| 23/04/22 14:30 | RB Leipzig | 1. FC Union Berlin | 1-2 |
| 23/04/22 14:30 | SpVgg Greuther Fürth | Bayer 04 Leverkusen | 1-4 |
| 23/04/22 14:30 | 1. FC Köln | Arminia Bielefeld | 3-1 |
| 23/04/22 14:30 | SC Freiburg | Bor. Mönchengladbach | 3-3 |
| 23/04/22 14:30 | Eintracht Frankfurt | 1899 Hoffenheim | 2-2 |
| 23/04/22 17:30 | FC Bayern Munich | Borussia Dortmund | 3-1 |
| 24/04/22 14:30 | VfL Bochum | FC Augsburg | 0-2 |
| 24/04/22 16:30 | Hertha BSC | VfB Stuttgart | 2-0 |