| Date | Home | Away | Result |
|---|---|---|---|
| 08/04/22 19:30 | VfB Stuttgart | Borussia Dortmund | 0-2 |
| 09/04/22 14:30 | 1. FC Köln | FSV Mainz 05 | 3-2 |
| 09/04/22 14:30 | VfL Wolfsburg | Arminia Bielefeld | 4-0 |
| 09/04/22 14:30 | FC Bayern Munich | FC Augsburg | 1-0 |
| 09/04/22 14:30 | SpVgg Greuther Fürth | Bor. Mönchengladbach | 0-2 |
| 09/04/22 17:30 | Hertha BSC | 1. FC Union Berlin | 1-4 |
| 10/04/22 14:30 | VfL Bochum | Bayer 04 Leverkusen | 0-0 |
| 10/04/22 16:30 | Eintracht Frankfurt | SC Freiburg | 1-2 |
| 10/04/22 18:30 | RB Leipzig | 1899 Hoffenheim | 3-0 |