| Date | Home | Away | Result |
|---|---|---|---|
| 01/04/22 19:30 | 1. FC Union Berlin | 1. FC Köln | 1-0 |
| 02/04/22 14:30 | Eintracht Frankfurt | SpVgg Greuther Fürth | 0-0 |
| 02/04/22 14:30 | Arminia Bielefeld | VfB Stuttgart | 1-1 |
| 02/04/22 14:30 | 1899 Hoffenheim | VfL Bochum | 1-2 |
| 02/04/22 14:30 | SC Freiburg | FC Bayern Munich | 1-4 |
| 02/04/22 14:30 | Bayer 04 Leverkusen | Hertha BSC | 2-1 |
| 02/04/22 17:30 | Borussia Dortmund | RB Leipzig | 1-4 |
| 03/04/22 14:30 | FC Augsburg | VfL Wolfsburg | 3-0 |
| 03/04/22 16:30 | Bor. Mönchengladbach | FSV Mainz 05 | 1-1 |