| Date | Home | Away | Result |
|---|---|---|---|
| 12/03/22 14:30 | 1899 Hoffenheim | FC Bayern Munich | 1-1 |
| 12/03/22 14:30 | SC Freiburg | VfL Wolfsburg | 3-2 |
| 12/03/22 14:30 | 1. FC Union Berlin | VfB Stuttgart | 1-1 |
| 12/03/22 17:30 | Bor. Mönchengladbach | Hertha BSC | 2-0 |
| 13/03/22 14:30 | Bayer 04 Leverkusen | 1. FC Köln | 0-1 |
| 13/03/22 16:30 | Borussia Dortmund | Arminia Bielefeld | 1-0 |
| 13/03/22 16:30 | Eintracht Frankfurt | VfL Bochum | 2-1 |
| 13/03/22 18:30 | SpVgg Greuther Fürth | RB Leipzig | 1-6 |
| 06/04/22 17:30 | FC Augsburg | FSV Mainz 05 | 2-1 |