| Date | Home | Away | Result |
|---|---|---|---|
| 21/01/22 19:30 | Eintracht Frankfurt | Arminia Bielefeld | 0-2 |
| 22/01/22 14:30 | Bor. Mönchengladbach | 1. FC Union Berlin | 1-2 |
| 22/01/22 14:30 | Bayer 04 Leverkusen | FC Augsburg | 5-1 |
| 22/01/22 14:30 | 1899 Hoffenheim | Borussia Dortmund | 2-3 |
| 22/01/22 14:30 | SC Freiburg | VfB Stuttgart | 2-0 |
| 22/01/22 14:30 | SpVgg Greuther Fürth | FSV Mainz 05 | 2-1 |
| 22/01/22 17:30 | VfL Bochum | 1. FC Köln | 2-2 |
| 23/01/22 14:30 | RB Leipzig | VfL Wolfsburg | 2-0 |
| 23/01/22 16:30 | Hertha BSC | FC Bayern Munich | 1-4 |