| Date | Home | Away | Result |
|---|---|---|---|
| 20/08/21 19:30 | RB Leipzig | VfB Stuttgart | 4-0 |
| 21/08/21 14:30 | SpVgg Greuther Fürth | Arminia Bielefeld | 1-1 |
| 21/08/21 14:30 | VfL Bochum | FSV Mainz 05 | 2-0 |
| 21/08/21 14:30 | SC Freiburg | Borussia Dortmund | 2-1 |
| 21/08/21 14:30 | Eintracht Frankfurt | FC Augsburg | 0-0 |
| 21/08/21 14:35 | Hertha BSC | VfL Wolfsburg | 1-2 |
| 21/08/21 17:30 | Bayer 04 Leverkusen | Bor. Mönchengladbach | 4-0 |
| 22/08/21 14:30 | 1899 Hoffenheim | 1. FC Union Berlin | 2-2 |
| 22/08/21 16:30 | FC Bayern Munich | 1. FC Köln | 3-2 |