| Date | Home | Away | Result |
|---|---|---|---|
| 14/12/21 17:30 | VfB Stuttgart | FC Bayern Munich | 0-5 |
| 14/12/21 19:30 | Arminia Bielefeld | VfL Bochum | 2-0 |
| 14/12/21 19:30 | FSV Mainz 05 | Hertha BSC | 4-0 |
| 14/12/21 19:30 | VfL Wolfsburg | 1. FC Köln | 2-3 |
| 15/12/21 17:30 | Bor. Mönchengladbach | Eintracht Frankfurt | 2-3 |
| 15/12/21 19:30 | FC Augsburg | RB Leipzig | 1-1 |
| 15/12/21 19:30 | 1. FC Union Berlin | SC Freiburg | 0-0 |
| 15/12/21 19:30 | Bayer 04 Leverkusen | 1899 Hoffenheim | 2-2 |
| 15/12/21 19:30 | Borussia Dortmund | SpVgg Greuther Fürth | 3-0 |