| Date | Home | Away | Result |
|---|---|---|---|
| 26/11/21 19:30 | VfB Stuttgart | FSV Mainz 05 | 2-1 |
| 27/11/21 14:30 | 1. FC Köln | Bor. Mönchengladbach | 4-1 |
| 27/11/21 14:30 | Hertha BSC | FC Augsburg | 1-1 |
| 27/11/21 14:30 | VfL Wolfsburg | Borussia Dortmund | 1-3 |
| 27/11/21 14:30 | SpVgg Greuther Fürth | 1899 Hoffenheim | 3-6 |
| 27/11/21 14:30 | VfL Bochum | SC Freiburg | 2-1 |
| 27/11/21 17:30 | FC Bayern Munich | Arminia Bielefeld | 1-0 |
| 28/11/21 14:30 | Eintracht Frankfurt | 1. FC Union Berlin | 2-1 |
| 28/11/21 16:30 | RB Leipzig | Bayer 04 Leverkusen | 1-3 |