| Date | Home | Away | Result |
|---|---|---|---|
| 28/10/22 19:30 | Werder Bremen | Hertha BSC | 1-0 |
| 29/10/22 14:30 | VfB Stuttgart | FC Augsburg | 2-1 |
| 29/10/22 14:30 | RB Leipzig | Bayer 04 Leverkusen | 2-0 |
| 29/10/22 14:30 | FC Bayern Munich | FSV Mainz 05 | 6-2 |
| 29/10/22 14:30 | VfL Wolfsburg | VfL Bochum | 4-0 |
| 29/10/22 17:30 | Eintracht Frankfurt | Borussia Dortmund | 1-2 |
| 30/10/22 14:30 | 1. FC Union Berlin | Bor. Mönchengladbach | 2-1 |
| 30/10/22 16:30 | FC Schalke 04 | SC Freiburg | 0-2 |
| 30/10/22 18:30 | 1. FC Köln | 1899 Hoffenheim | 1-1 |