| Date | Home | Away | Result |
|---|---|---|---|
| 20/02/25 17:45 | FK Bodö/Glimt | FC Twente Enschede | 5-2a.e.t |
| 20/02/25 17:45 | FCSB Bukarest | PAOK Saloniki | 2-0 |
| 20/02/25 17:45 | Galatasaray Istanbul | AZ Alkmaar | 2-2 |
| 20/02/25 17:45 | AS Roma | FC Porto | 3-2 |
| 20/02/25 20:00 | RSC Anderlecht | Fenerbahce Istanbul | 2-2 |
| 20/02/25 20:00 | Ajax Amsterdam | Royale Union Saint-Gilloise | 1-2a.e.t |
| 20/02/25 20:00 | Real Sociedad | FC Midtjylland | 5-2 |
| 20/02/25 20:00 | Viktoria Plzen | Ferencvaros Budapest | 3-0 |