| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 17/09/21 17:30 | 17/09/21 17:15 | 1. FC Nürnberg | FC Hansa Rostock | 1-0 | 2 - 4 points |
| 17/09/21 17:30 | 17/09/21 17:15 | FC Schalke 04 | Karlsruher SC | 1-2 | 2 - 4 points |
| 18/09/21 12:30 | 18/09/21 12:15 | Fortuna Düsseldorf | Jahn Regensburg | 1-1 | 2 - 4 points |
| 18/09/21 12:30 | 18/09/21 12:15 | SV Sandhausen | 1. FC Heidenheim 1846 | 1-3 | 2 - 4 points |
| 18/09/21 12:30 | 18/09/21 12:15 | Holstein Kiel | Hannover 96 | 0-3 | 2 - 4 points |
| 18/09/21 19:30 | 18/09/21 19:15 | Werder Bremen | Hamburger SV | 0-2 | 2 - 4 points |
| 19/09/21 12:30 | 19/09/21 12:15 | SV Darmstadt 98 | Dynamo Dresden | 1-0 | 2 - 4 points |
| 19/09/21 12:30 | 19/09/21 12:15 | FC St. Pauli | FC Ingolstadt | 4-1 | 2 - 4 points |
| 19/09/21 12:30 | 19/09/21 12:15 | Erzgebirge Aue | SC Paderborn 07 | 1-4 | 2 - 4 points |