| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 11/09/21 12:30 | 11/09/21 12:15 | FC Ingolstadt | Werder Bremen | 0-3 | 2 - 4 points |
| 11/09/21 12:30 | 11/09/21 12:15 | Karlsruher SC | Holstein Kiel | 2-2 | 2 - 4 points |
| 11/09/21 12:30 | 11/09/21 12:15 | Hannover 96 | FC St. Pauli | 1-0 | 2 - 4 points |
| 11/09/21 19:30 | 11/09/21 19:15 | Hamburger SV | SV Sandhausen | 2-1 | 2 - 4 points |
| 12/09/21 12:30 | 12/09/21 12:15 | Jahn Regensburg | 1. FC Nürnberg | 2-2 | 2 - 4 points |
| 12/09/21 12:30 | 12/09/21 12:15 | FC Hansa Rostock | SV Darmstadt 98 | 2-1 | 2 - 4 points |
| 12/09/21 12:30 | 12/09/21 12:15 | 1. FC Heidenheim 1846 | Dynamo Dresden | 2-1 | 2 - 4 points |
| 12/09/21 12:30 | 12/09/21 12:15 | SC Paderborn 07 | FC Schalke 04 | 0-1 | 2 - 4 points |
| 12/09/21 12:30 | 12/09/21 12:15 | Erzgebirge Aue | Fortuna Düsseldorf | 0-1 | 2 - 4 points |