| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 20/08/21 17:30 | 20/08/21 17:15 | Fortuna Düsseldorf | Holstein Kiel | 2-2 | 2 - 4 points |
| 20/08/21 17:30 | 20/08/21 17:15 | Hannover 96 | 1. FC Heidenheim 1846 | 1-0 | 2 - 4 points |
| 21/08/21 12:30 | 21/08/21 12:15 | Karlsruher SC | Werder Bremen | 0-0 | 2 - 4 points |
| 21/08/21 12:30 | 21/08/21 12:15 | SC Paderborn 07 | FC St. Pauli | 3-1 | 2 - 4 points |
| 21/08/21 12:30 | 21/08/21 12:15 | Jahn Regensburg | FC Schalke 04 | 4-1 | 2 - 4 points |
| 21/08/21 19:30 | 21/08/21 19:15 | FC Hansa Rostock | Dynamo Dresden | 1-3 | 2 - 4 points |
| 22/08/21 12:30 | 22/08/21 12:15 | Erzgebirge Aue | SV Sandhausen | 1-3 | 2 - 4 points |
| 22/08/21 12:30 | 22/08/21 12:15 | FC Ingolstadt | 1. FC Nürnberg | 0-0 | 2 - 4 points |
| 22/08/21 12:30 | 22/08/21 12:15 | Hamburger SV | SV Darmstadt 98 | 2-2 | 2 - 4 points |