| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 06/05/22 17:30 | 06/05/22 17:15 | Fortuna Düsseldorf | SV Darmstadt 98 | 2-1 | 2 - 4 points |
| 06/05/22 17:30 | 06/05/22 17:15 | SC Paderborn 07 | SV Sandhausen | 2-0 | 2 - 4 points |
| 07/05/22 12:30 | 07/05/22 12:15 | Hamburger SV | Hannover 96 | 2-1 | 2 - 4 points |
| 07/05/22 12:30 | 07/05/22 12:15 | Jahn Regensburg | 1. FC Heidenheim 1846 | 0-2 | 2 - 4 points |
| 07/05/22 12:30 | 07/05/22 12:15 | FC Ingolstadt | FC Hansa Rostock | 0-0 | 2 - 4 points |
| 07/05/22 19:30 | 07/05/22 19:15 | FC Schalke 04 | FC St. Pauli | 3-2 | 2 - 4 points |
| 08/05/22 12:30 | 08/05/22 12:15 | Holstein Kiel | 1. FC Nürnberg | 3-0 | 2 - 4 points |
| 08/05/22 12:30 | 08/05/22 12:15 | Karlsruher SC | Dynamo Dresden | 2-2 | 2 - 4 points |
| 08/05/22 12:30 | 08/05/22 12:15 | Erzgebirge Aue | Werder Bremen | 0-3 | 2 - 4 points |