| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 29/04/22 17:30 | 29/04/22 17:15 | 1. FC Heidenheim 1846 | Fortuna Düsseldorf | 1-3 | 2 - 4 points |
| 29/04/22 17:30 | 29/04/22 17:15 | FC St. Pauli | 1. FC Nürnberg | 1-1 | 2 - 4 points |
| 29/04/22 17:30 | 29/04/22 17:15 | Hannover 96 | Karlsruher SC | 2-0 | 2 - 4 points |
| 29/04/22 17:30 | 29/04/22 17:15 | SV Sandhausen | FC Schalke 04 | 1-2 | 2 - 4 points |
| 29/04/22 17:30 | 29/04/22 17:15 | Werder Bremen | Holstein Kiel | 2-3 | 2 - 4 points |
| 30/04/22 12:30 | 30/04/22 12:15 | Dynamo Dresden | Jahn Regensburg | 1-1 | 2 - 4 points |
| 30/04/22 12:30 | 30/04/22 12:15 | FC Hansa Rostock | SC Paderborn 07 | 0-0 | 2 - 4 points |
| 30/04/22 12:30 | 30/04/22 12:15 | FC Ingolstadt | Hamburger SV | 0-4 | 2 - 4 points |
| 30/04/22 19:30 | 30/04/22 19:15 | SV Darmstadt 98 | Erzgebirge Aue | 6-0 | 2 - 4 points |