| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 22/04/22 17:30 | 22/04/22 17:15 | Fortuna Düsseldorf | Dynamo Dresden | 2-2 | 2 - 4 points |
| 22/04/22 17:30 | 22/04/22 17:15 | Karlsruher SC | FC Ingolstadt | 2-2 | 2 - 4 points |
| 23/04/22 12:30 | 23/04/22 12:15 | FC Schalke 04 | Werder Bremen | 1-4 | 2 - 4 points |
| 23/04/22 12:30 | 23/04/22 12:15 | Holstein Kiel | 1. FC Heidenheim 1846 | 1-1 | 2 - 4 points |
| 23/04/22 12:30 | 23/04/22 12:15 | Jahn Regensburg | Hamburger SV | 2-4 | 2 - 4 points |
| 23/04/22 19:30 | 23/04/22 19:15 | FC St. Pauli | SV Darmstadt 98 | 1-2 | 2 - 4 points |
| 24/04/22 12:30 | 24/04/22 12:15 | SC Paderborn 07 | Hannover 96 | 3-0 | 2 - 4 points |
| 24/04/22 12:30 | 24/04/22 12:15 | 1. FC Nürnberg | SV Sandhausen | 2-4 | 2 - 4 points |
| 24/04/22 12:30 | 24/04/22 12:15 | Erzgebirge Aue | FC Hansa Rostock | 2-2 | 2 - 4 points |