| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 13/08/21 17:30 | 13/08/21 17:15 | FC Schalke 04 | Erzgebirge Aue | 1-1 | 2 - 4 points |
| 13/08/21 17:30 | 13/08/21 17:15 | FC St. Pauli | Hamburger SV | 3-2 | 2 - 4 points |
| 14/08/21 12:30 | 14/08/21 12:15 | Holstein Kiel | Jahn Regensburg | 0-3 | 2 - 4 points |
| 14/08/21 12:30 | 14/08/21 12:15 | 1. FC Nürnberg | Fortuna Düsseldorf | 2-0 | 2 - 4 points |
| 14/08/21 12:30 | 14/08/21 12:15 | SV Sandhausen | Karlsruher SC | 0-0 | 2 - 4 points |
| 14/08/21 19:30 | 14/08/21 19:15 | Dynamo Dresden | Hannover 96 | 2-0 | 2 - 4 points |
| 15/08/21 12:30 | 15/08/21 12:15 | Werder Bremen | SC Paderborn 07 | 1-4 | 2 - 4 points |
| 15/08/21 12:30 | 15/08/21 12:15 | SV Darmstadt 98 | FC Ingolstadt | 6-1 | 2 - 4 points |
| 15/08/21 12:30 | 15/08/21 12:15 | 1. FC Heidenheim 1846 | FC Hansa Rostock | 1-1 | 2 - 4 points |