| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 01/04/22 17:30 | 01/04/22 17:15 | Dynamo Dresden | FC Schalke 04 | 1-2 | 2 - 4 points |
| 01/04/22 17:30 | 01/04/22 17:15 | FC Ingolstadt | Erzgebirge Aue | 3-2 | 2 - 4 points |
| 02/04/22 12:30 | 02/04/22 12:15 | Hamburger SV | SC Paderborn 07 | 1-2 | 2 - 4 points |
| 02/04/22 12:30 | 02/04/22 12:15 | SV Darmstadt 98 | Holstein Kiel | 3-1 | 2 - 4 points |
| 02/04/22 12:30 | 02/04/22 12:15 | Hannover 96 | Jahn Regensburg | 1-1 | 2 - 4 points |
| 02/04/22 19:30 | 02/04/22 19:15 | FC Hansa Rostock | FC St. Pauli | 1-0 | 2 - 4 points |
| 03/04/22 12:30 | 03/04/22 12:15 | Werder Bremen | SV Sandhausen | 1-1 | 2 - 4 points |
| 03/04/22 12:30 | 03/04/22 12:15 | Karlsruher SC | Fortuna Düsseldorf | 2-2 | 2 - 4 points |
| 03/04/22 12:30 | 03/04/22 12:15 | 1. FC Heidenheim 1846 | 1. FC Nürnberg | 3-1 | 2 - 4 points |