| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 18/03/22 17:30 | 18/03/22 17:15 | FC St. Pauli | 1. FC Heidenheim 1846 | 1-0 | 2 - 4 points |
| 18/03/22 17:30 | 18/03/22 17:15 | Erzgebirge Aue | Karlsruher SC | 0-3 | 2 - 4 points |
| 19/03/22 12:30 | 19/03/22 12:15 | FC Schalke 04 | Hannover 96 | 2-1 | 2 - 4 points |
| 19/03/22 12:30 | 19/03/22 12:15 | Fortuna Düsseldorf | Hamburger SV | 1-1 | 2 - 4 points |
| 19/03/22 12:30 | 19/03/22 12:15 | SV Sandhausen | FC Hansa Rostock | 0-1 | 2 - 4 points |
| 19/03/22 19:30 | 19/03/22 19:15 | Werder Bremen | SV Darmstadt 98 | 1-0 | 2 - 4 points |
| 20/03/22 12:30 | 20/03/22 12:15 | Holstein Kiel | FC Ingolstadt | 1-0 | 2 - 4 points |
| 20/03/22 12:30 | 20/03/22 12:15 | 1. FC Nürnberg | Dynamo Dresden | 1-1 | 2 - 4 points |
| 20/03/22 12:30 | 20/03/22 12:15 | Jahn Regensburg | SC Paderborn 07 | 1-0 | 2 - 4 points |