| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 11/03/22 17:30 | 11/03/22 17:15 | SV Darmstadt 98 | SV Sandhausen | 1-1 | 2 - 4 points |
| 11/03/22 17:30 | 11/03/22 17:15 | FC Hansa Rostock | Holstein Kiel | 3-2 | 2 - 4 points |
| 12/03/22 12:30 | 12/03/22 12:15 | SC Paderborn 07 | Fortuna Düsseldorf | 1-1 | 2 - 4 points |
| 12/03/22 12:30 | 12/03/22 12:15 | Dynamo Dresden | FC St. Pauli | 1-1 | 2 - 4 points |
| 12/03/22 19:30 | 12/03/22 19:15 | 1. FC Heidenheim 1846 | Werder Bremen | 2-1 | 2 - 4 points |
| 13/03/22 12:30 | 13/03/22 12:15 | Karlsruher SC | Jahn Regensburg | 1-1 | 2 - 4 points |
| 13/03/22 12:30 | 13/03/22 12:15 | Hannover 96 | 1. FC Nürnberg | 0-3 | 2 - 4 points |
| 13/03/22 12:30 | 13/03/22 12:15 | FC Ingolstadt | FC Schalke 04 | 0-3 | 2 - 4 points |
| 05/04/22 17:30 | 05/04/22 17:15 | Hamburger SV | Erzgebirge Aue | 4-0 | 2 - 4 points |