| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 25/02/22 17:30 | 25/02/22 17:15 | Hannover 96 | Holstein Kiel | 2-0 | 2 - 4 points |
| 25/02/22 17:30 | 25/02/22 17:15 | SC Paderborn 07 | Erzgebirge Aue | 3-3 | 2 - 4 points |
| 26/02/22 12:30 | 26/02/22 12:15 | FC Hansa Rostock | 1. FC Nürnberg | 0-2 | 2 - 4 points |
| 26/02/22 12:30 | 26/02/22 12:15 | FC Ingolstadt | FC St. Pauli | 1-3 | 2 - 4 points |
| 26/02/22 12:30 | 26/02/22 12:15 | Karlsruher SC | FC Schalke 04 | 1-1 | 2 - 4 points |
| 26/02/22 19:30 | 26/02/22 19:15 | Dynamo Dresden | SV Darmstadt 98 | 0-1 | 2 - 4 points |
| 27/02/22 12:30 | 27/02/22 12:15 | Jahn Regensburg | Fortuna Düsseldorf | 0-0 | 2 - 4 points |
| 27/02/22 12:30 | 27/02/22 12:15 | Hamburger SV | Werder Bremen | 2-3 | 2 - 4 points |
| 27/02/22 12:30 | 27/02/22 12:15 | 1. FC Heidenheim 1846 | SV Sandhausen | 1-1 | 2 - 4 points |