| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 18/02/22 17:30 | 18/02/22 17:15 | Dynamo Dresden | 1. FC Heidenheim 1846 | 1-1 | 2 - 4 points |
| 18/02/22 17:30 | 18/02/22 17:15 | FC Schalke 04 | SC Paderborn 07 | 2-0 | 2 - 4 points |
| 19/02/22 12:30 | 19/02/22 12:15 | Werder Bremen | FC Ingolstadt | 1-1 | 2 - 4 points |
| 19/02/22 12:30 | 19/02/22 12:15 | Holstein Kiel | Karlsruher SC | 0-2 | 2 - 4 points |
| 19/02/22 12:30 | 19/02/22 12:15 | SV Sandhausen | Hamburger SV | 1-1 | 2 - 4 points |
| 19/02/22 19:30 | 19/02/22 19:15 | 1. FC Nürnberg | Jahn Regensburg | 2-0 | 2 - 4 points |
| 20/02/22 12:30 | 20/02/22 12:15 | Fortuna Düsseldorf | Erzgebirge Aue | 3-1 | 2 - 4 points |
| 20/02/22 12:30 | 20/02/22 12:15 | SV Darmstadt 98 | FC Hansa Rostock | 1-1 | 2 - 4 points |
| 20/02/22 12:30 | 20/02/22 12:15 | FC St. Pauli | Hannover 96 | 0-3 | 2 - 4 points |