| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 04/02/22 17:30 | 04/02/22 17:15 | 1. FC Heidenheim 1846 | Hannover 96 | 3-1 | 2 - 4 points |
| 04/02/22 17:30 | 04/02/22 17:15 | 1. FC Nürnberg | FC Ingolstadt | 0-5 | 2 - 4 points |
| 05/02/22 12:30 | 05/02/22 12:15 | SV Sandhausen | Erzgebirge Aue | 2-0 | 2 - 4 points |
| 05/02/22 12:30 | 05/02/22 12:15 | Werder Bremen | Karlsruher SC | 2-1 | 2 - 4 points |
| 05/02/22 12:30 | 05/02/22 12:15 | FC Schalke 04 | Jahn Regensburg | 2-1 | 2 - 4 points |
| 05/02/22 19:30 | 05/02/22 19:15 | FC St. Pauli | SC Paderborn 07 | 2-2 | 2 - 4 points |
| 06/02/22 12:30 | 06/02/22 12:15 | SV Darmstadt 98 | Hamburger SV | 0-5 | 2 - 4 points |
| 06/02/22 12:30 | 06/02/22 12:15 | Dynamo Dresden | FC Hansa Rostock | 1-4 | 2 - 4 points |
| 06/02/22 12:30 | 06/02/22 12:15 | Holstein Kiel | Fortuna Düsseldorf | 1-0 | 2 - 4 points |