| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 21/01/22 17:30 | 21/01/22 17:15 | Hamburger SV | FC St. Pauli | 2-1 | 2 - 4 points |
| 21/01/22 17:30 | 21/01/22 17:15 | Fortuna Düsseldorf | 1. FC Nürnberg | 0-1 | 2 - 4 points |
| 22/01/22 12:30 | 22/01/22 12:15 | FC Ingolstadt | SV Darmstadt 98 | 0-2 | 2 - 4 points |
| 22/01/22 12:30 | 22/01/22 12:15 | SC Paderborn 07 | Werder Bremen | 3-4 | 2 - 4 points |
| 22/01/22 12:30 | 22/01/22 12:15 | FC Hansa Rostock | 1. FC Heidenheim 1846 | 0-0 | 2 - 4 points |
| 22/01/22 19:30 | 22/01/22 19:15 | Erzgebirge Aue | FC Schalke 04 | 0-5 | 2 - 4 points |
| 23/01/22 12:30 | 23/01/22 12:15 | Hannover 96 | Dynamo Dresden | 0-0 | 2 - 4 points |
| 23/01/22 12:30 | 23/01/22 12:15 | Jahn Regensburg | Holstein Kiel | 1-2 | 2 - 4 points |
| 08/02/22 17:30 | 08/02/22 17:15 | Karlsruher SC | SV Sandhausen | 0-2 | 2 - 4 points |