| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 30/07/21 17:30 | 30/07/21 17:15 | SC Paderborn 07 | 1. FC Nürnberg | 2-2 | 2 - 4 points |
| 30/07/21 17:30 | 30/07/21 17:15 | Karlsruher SC | SV Darmstadt 98 | 3-0 | 2 - 4 points |
| 31/07/21 12:30 | 31/07/21 12:15 | Hannover 96 | FC Hansa Rostock | 0-3 | 2 - 4 points |
| 31/07/21 12:30 | 31/07/21 12:15 | Jahn Regensburg | SV Sandhausen | 3-0 | 2 - 4 points |
| 31/07/21 12:30 | 31/07/21 12:15 | FC Ingolstadt | 1. FC Heidenheim 1846 | 1-2 | 2 - 4 points |
| 31/07/21 19:30 | 31/07/21 19:15 | Fortuna Düsseldorf | Werder Bremen | 2-3 | 2 - 4 points |
| 01/08/21 12:30 | 01/08/21 12:15 | Erzgebirge Aue | FC St. Pauli | 0-0 | 2 - 4 points |
| 01/08/21 12:30 | 01/08/21 12:15 | Holstein Kiel | FC Schalke 04 | 0-3 | 2 - 4 points |
| 01/08/21 12:30 | 01/08/21 12:15 | Hamburger SV | Dynamo Dresden | 1-1 | 2 - 4 points |