| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 17/12/21 17:30 | 17/12/21 17:15 | Fortuna Düsseldorf | SV Sandhausen | 0-1 | 2 - 4 points |
| 17/12/21 17:30 | 17/12/21 17:15 | Holstein Kiel | FC St. Pauli | 3-0 | 2 - 4 points |
| 18/12/21 12:30 | 18/12/21 12:15 | SC Paderborn 07 | 1. FC Heidenheim 1846 | 1-2 | 2 - 4 points |
| 18/12/21 12:30 | 18/12/21 12:15 | Erzgebirge Aue | 1. FC Nürnberg | 1-3 | 2 - 4 points |
| 18/12/21 12:30 | 18/12/21 12:15 | FC Ingolstadt | Dynamo Dresden | 3-0 | 2 - 4 points |
| 18/12/21 19:30 | 18/12/21 19:15 | Hamburger SV | FC Schalke 04 | 1-1 | 2 - 4 points |
| 19/12/21 12:30 | 19/12/21 12:15 | Karlsruher SC | FC Hansa Rostock | 2-2 | 2 - 4 points |
| 19/12/21 12:30 | 19/12/21 12:15 | Hannover 96 | Werder Bremen | 1-4 | 2 - 4 points |
| 19/12/21 12:30 | 19/12/21 12:15 | Jahn Regensburg | SV Darmstadt 98 | 0-2 | 2 - 4 points |