| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 03/12/21 17:30 | 03/12/21 17:15 | Werder Bremen | Erzgebirge Aue | 4-0 | 2 - 4 points |
| 03/12/21 17:30 | 03/12/21 17:15 | SV Darmstadt 98 | Fortuna Düsseldorf | 1-3 | 2 - 4 points |
| 04/12/21 12:30 | 04/12/21 12:15 | 1. FC Nürnberg | Holstein Kiel | 2-1 | 2 - 4 points |
| 04/12/21 12:30 | 04/12/21 12:15 | SV Sandhausen | SC Paderborn 07 | 1-1 | 2 - 4 points |
| 04/12/21 12:30 | 04/12/21 12:15 | FC Hansa Rostock | FC Ingolstadt | 1-1 | 2 - 4 points |
| 04/12/21 19:30 | 04/12/21 19:15 | FC St. Pauli | FC Schalke 04 | 2-1 | 2 - 4 points |
| 05/12/21 12:30 | 05/12/21 12:15 | Hannover 96 | Hamburger SV | 1-0 | 2 - 4 points |
| 05/12/21 12:30 | 05/12/21 12:15 | Dynamo Dresden | Karlsruher SC | 3-1 | 2 - 4 points |
| 05/12/21 12:30 | 05/12/21 12:15 | 1. FC Heidenheim 1846 | Jahn Regensburg | 3-0 | 2 - 4 points |