| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 26/11/21 17:30 | 26/11/21 17:15 | Jahn Regensburg | Dynamo Dresden | 3-1 | 2 - 4 points |
| 26/11/21 17:30 | 26/11/21 17:15 | Fortuna Düsseldorf | 1. FC Heidenheim 1846 | 0-1 | 2 - 4 points |
| 27/11/21 12:30 | 27/11/21 12:15 | Karlsruher SC | Hannover 96 | 4-0 | 2 - 4 points |
| 27/11/21 12:30 | 27/11/21 12:15 | Erzgebirge Aue | SV Darmstadt 98 | 1-2 | 2 - 4 points |
| 27/11/21 12:30 | 27/11/21 12:15 | FC Schalke 04 | SV Sandhausen | 5-2 | 2 - 4 points |
| 27/11/21 19:30 | 27/11/21 19:15 | Holstein Kiel | Werder Bremen | 2-1 | 2 - 4 points |
| 28/11/21 12:30 | 28/11/21 12:15 | SC Paderborn 07 | FC Hansa Rostock | 1-1 | 2 - 4 points |
| 28/11/21 12:30 | 28/11/21 12:15 | 1. FC Nürnberg | FC St. Pauli | 2-3 | 2 - 4 points |
| 28/11/21 12:30 | 28/11/21 12:15 | Hamburger SV | FC Ingolstadt | 3-0 | 2 - 4 points |