| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 19/11/21 17:30 | 19/11/21 17:15 | Hannover 96 | SC Paderborn 07 | 0-0 | 2 - 4 points |
| 19/11/21 17:30 | 19/11/21 17:15 | SV Sandhausen | 1. FC Nürnberg | 1-2 | 2 - 4 points |
| 20/11/21 12:30 | 20/11/21 12:15 | FC Hansa Rostock | Erzgebirge Aue | 1-2 | 2 - 4 points |
| 20/11/21 12:30 | 20/11/21 12:15 | Hamburger SV | Jahn Regensburg | 4-1 | 2 - 4 points |
| 20/11/21 12:30 | 20/11/21 12:15 | SV Darmstadt 98 | FC St. Pauli | 4-0 | 2 - 4 points |
| 20/11/21 19:30 | 20/11/21 19:15 | Werder Bremen | FC Schalke 04 | 1-1 | 2 - 4 points |
| 21/11/21 12:30 | 21/11/21 12:15 | FC Ingolstadt | Karlsruher SC | 1-1 | 2 - 4 points |
| 21/11/21 12:30 | 21/11/21 12:15 | 1. FC Heidenheim 1846 | Holstein Kiel | 2-1 | 2 - 4 points |
| 21/11/21 12:30 | 21/11/21 12:15 | Dynamo Dresden | Fortuna Düsseldorf | 1-0 | 2 - 4 points |