| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 05/11/21 17:30 | 05/11/21 17:15 | Holstein Kiel | Dynamo Dresden | 2-1 | 2 - 4 points |
| 05/11/21 17:30 | 05/11/21 17:15 | 1. FC Nürnberg | Werder Bremen | 1-2 | 2 - 4 points |
| 06/11/21 12:30 | 06/11/21 12:15 | Fortuna Düsseldorf | Hannover 96 | 1-1 | 2 - 4 points |
| 06/11/21 12:30 | 06/11/21 12:15 | SC Paderborn 07 | FC Ingolstadt | 2-1 | 2 - 4 points |
| 06/11/21 12:30 | 06/11/21 12:15 | Jahn Regensburg | FC Hansa Rostock | 2-3 | 2 - 4 points |
| 06/11/21 19:30 | 06/11/21 19:15 | Karlsruher SC | Hamburger SV | 1-1 | 2 - 4 points |
| 07/11/21 12:30 | 07/11/21 12:15 | Erzgebirge Aue | 1. FC Heidenheim 1846 | 2-0 | 2 - 4 points |
| 07/11/21 12:30 | 07/11/21 12:15 | FC Schalke 04 | SV Darmstadt 98 | 2-4 | 2 - 4 points |
| 24/11/21 17:30 | 24/11/21 17:15 | FC St. Pauli | SV Sandhausen | 3-1 | 2 - 4 points |