| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 29/10/21 17:30 | 29/10/21 17:15 | SV Darmstadt 98 | 1. FC Nürnberg | 2-0 | 2 - 4 points |
| 29/10/21 17:30 | 29/10/21 17:15 | 1. FC Heidenheim 1846 | FC Schalke 04 | 1-0 | 2 - 4 points |
| 30/10/21 12:30 | 30/10/21 12:15 | Werder Bremen | FC St. Pauli | 1-1 | 2 - 4 points |
| 30/10/21 12:30 | 30/10/21 12:15 | Hannover 96 | Erzgebirge Aue | 1-1 | 2 - 4 points |
| 30/10/21 12:30 | 30/10/21 12:15 | Dynamo Dresden | SV Sandhausen | 0-1 | 2 - 4 points |
| 30/10/21 19:30 | 30/10/21 19:15 | Hamburger SV | Holstein Kiel | 1-1 | 2 - 4 points |
| 31/10/21 12:30 | 31/10/21 12:15 | Karlsruher SC | SC Paderborn 07 | 2-4 | 2 - 4 points |
| 31/10/21 12:30 | 31/10/21 12:15 | FC Hansa Rostock | Fortuna Düsseldorf | 2-1 | 2 - 4 points |
| 31/10/21 12:30 | 31/10/21 12:15 | FC Ingolstadt | Jahn Regensburg | 0-3 | 2 - 4 points |