| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 23/07/21 19:30 | 23/07/21 19:15 | FC Schalke 04 | Hamburger SV | 1-3 | 2 - 4 points |
| 24/07/21 12:30 | 24/07/21 12:15 | SV Darmstadt 98 | Jahn Regensburg | 0-2 | 2 - 4 points |
| 24/07/21 12:30 | 24/07/21 12:15 | 1. FC Heidenheim 1846 | SC Paderborn 07 | 0-0 | 2 - 4 points |
| 24/07/21 12:30 | 24/07/21 12:15 | Dynamo Dresden | FC Ingolstadt | 3-0 | 2 - 4 points |
| 24/07/21 12:30 | 24/07/21 12:15 | FC Hansa Rostock | Karlsruher SC | 1-3 | 2 - 4 points |
| 24/07/21 19:30 | 24/07/21 19:15 | Werder Bremen | Hannover 96 | 1-1 | 2 - 4 points |
| 25/07/21 12:30 | 25/07/21 12:15 | FC St. Pauli | Holstein Kiel | 3-0 | 2 - 4 points |
| 25/07/21 12:30 | 25/07/21 12:15 | 1. FC Nürnberg | Erzgebirge Aue | 0-0 | 2 - 4 points |
| 25/07/21 12:30 | 25/07/21 12:15 | SV Sandhausen | Fortuna Düsseldorf | 0-2 | 2 - 4 points |