Schedule
| Competition | Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|---|
| DFB | 01/03/22 19:45 | 01/03/22 19:45 | 1. FC Union Berlin | FC St. Pauli | 2-1 | 2 - 5 points |
| DFB | 02/03/22 17:30 | 02/03/22 17:30 | Hamburger SV | Karlsruher SC | 5-4a.PSO | 2 - 5 points |
| DFB | 02/03/22 17:30 | 02/03/22 17:30 | Hannover 96 | RB Leipzig | 0-4 | 2 - 5 points |
| DFB | 02/03/22 19:45 | 02/03/22 19:45 | VfL Bochum | SC Freiburg | 1-2a.e.t | 2 - 5 points |
| 2.BL | 04/03/22 17:30 | 04/03/22 17:30 | SV Darmstadt 98 | 1. FC Heidenheim 1846 | 3-2 | 2 - 5 points |
| 2.BL | 04/03/22 17:30 | 04/03/22 17:30 | Holstein Kiel | SC Paderborn 07 | 3-4 | 2 - 5 points |
| 2.BL | 05/03/22 12:30 | 05/03/22 12:30 | FC St. Pauli | Karlsruher SC | 3-1 | 2 - 5 points |
| 2.BL | 05/03/22 12:30 | 05/03/22 12:30 | SV Sandhausen | Hannover 96 | 3-1 | 2 - 5 points |
| 2.BL | 05/03/22 12:30 | 05/03/22 12:30 | FC Schalke 04 | FC Hansa Rostock | 3-4 | 2 - 5 points |
| GER1 | 05/03/22 17:30 | 05/03/22 17:30 | VfB Stuttgart | Bor. Mönchengladbach | 3-2 | 2 - 5 points |
| L2 | 05/03/22 18:00 | 05/03/22 18:00 | AS Nancy-Lorraine | Grenoble Foot | 0-1 | 2 - 5 points |
| 2.BL | 05/03/22 19:30 | 05/03/22 19:30 | 1. FC Nürnberg | Hamburger SV | 2-1 | 2 - 5 points |
| 2.BL | 06/03/22 12:30 | 06/03/22 12:30 | Erzgebirge Aue | Jahn Regensburg | 1-0 | 2 - 5 points |
| 2.BL | 06/03/22 12:30 | 06/03/22 12:30 | Werder Bremen | Dynamo Dresden | 2-1 | 2 - 5 points |
| 2.BL | 06/03/22 12:30 | 06/03/22 12:30 | Fortuna Düsseldorf | FC Ingolstadt | 3-0 | 2 - 5 points |