| Date | Home | Away | Result | Points rule |
|---|---|---|---|---|
| 16/09/22 17:30 | SV Sandhausen | Hannover 96 | 2-3 | 2 - 5 points |
| 16/09/22 17:30 | Eintracht Braunschweig | Karlsruher SC | 2-1 | 2 - 5 points |
| 17/09/22 12:00 | FC Hansa Rostock | 1. FC Magdeburg | 3-1 | 2 - 5 points |
| 17/09/22 12:00 | SV Darmstadt 98 | 1. FC Nürnberg | 2-0 | 2 - 5 points |
| 17/09/22 12:00 | Arminia Bielefeld | Holstein Kiel | 4-2 | 2 - 5 points |
| 17/09/22 19:30 | Hamburger SV | Fortuna Düsseldorf | 2-0 | 2 - 5 points |
| 18/09/22 12:30 | 1. FC Heidenheim 1846 | 1. FC Kaiserslautern | 2-2 | 2 - 5 points |
| 18/09/22 12:30 | SpVgg Greuther Fürth | SC Paderborn 07 | 2-1 | 2 - 5 points |
| 18/09/22 12:30 | Jahn Regensburg | FC St. Pauli | 2-0 | 2 - 5 points |
| 18/09/22 15:00 | KAS Eupen | Royale Union Saint-Gilloise | 1-2 | 2 - 5 points |