| Date | Home | Away | Result | Points rule |
|---|---|---|---|---|
| 11/02/22 17:30 | FC Hansa Rostock | Werder Bremen | 1-2 | 2 - 5 points |
| 11/02/22 17:30 | Erzgebirge Aue | Holstein Kiel | 2-3 | 2 - 5 points |
| 12/02/22 12:30 | Hamburger SV | 1. FC Heidenheim 1846 | 2-0 | 2 - 5 points |
| 12/02/22 12:30 | Karlsruher SC | 1. FC Nürnberg | 4-1 | 2 - 5 points |
| 12/02/22 12:30 | SC Paderborn 07 | Dynamo Dresden | 0-0 | 2 - 5 points |
| 12/02/22 17:30 | Bayer 04 Leverkusen | VfB Stuttgart | 4-2 | 2 - 5 points |
| 12/02/22 18:00 | Grenoble Foot | FC Sochaux | 1-3 | 2 - 5 points |
| 12/02/22 19:30 | Jahn Regensburg | FC St. Pauli | 2-3 | 2 - 5 points |
| 13/02/22 12:30 | FC Ingolstadt | SV Sandhausen | 0-0 | 2 - 5 points |
| 13/02/22 12:30 | Fortuna Düsseldorf | FC Schalke 04 | 2-1 | 2 - 5 points |
| 13/02/22 12:30 | Hannover 96 | SV Darmstadt 98 | 2-2 | 2 - 5 points |
| 13/02/22 15:00 | Royale Union Saint-Gilloise | Sint-Truidense VV | 0-1 | 2 - 5 points |