| Date | Home | Away | Result | Points rule |
|---|---|---|---|---|
| 03/12/21 17:30 | Werder Bremen | Erzgebirge Aue | 4-0 | 2 - 5 points |
| 03/12/21 17:30 | SV Darmstadt 98 | Fortuna Düsseldorf | 1-3 | 2 - 5 points |
| 03/12/21 19:45 | Sint-Truidense VV | Royale Union Saint-Gilloise | 1-2 | 2 - 5 points |
| 03/12/21 20:00 | Grenoble Foot | Havre AC | 1-2 | 2 - 5 points |
| 04/12/21 12:30 | 1. FC Nürnberg | Holstein Kiel | 2-1 | 2 - 5 points |
| 04/12/21 12:30 | SV Sandhausen | SC Paderborn 07 | 1-1 | 2 - 5 points |
| 04/12/21 12:30 | FC Hansa Rostock | FC Ingolstadt | 1-1 | 2 - 5 points |
| 04/12/21 19:30 | FC St. Pauli | FC Schalke 04 | 2-1 | 2 - 5 points |
| 05/12/21 12:30 | Hannover 96 | Hamburger SV | 1-0 | 2 - 5 points |
| 05/12/21 12:30 | Dynamo Dresden | Karlsruher SC | 3-1 | 2 - 5 points |
| 05/12/21 12:30 | 1. FC Heidenheim 1846 | Jahn Regensburg | 3-0 | 2 - 5 points |
| 05/12/21 14:30 | VfB Stuttgart | Hertha BSC | 2-2 | 2 - 5 points |