Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 18/02/22 19:30 | 18/02/22 19:00 | FSV Mainz 05 | Bayer 04 Leverkusen | 3-2 | 1 point |
| 19/02/22 14:30 | 18/02/22 19:00 | FC Augsburg | SC Freiburg | 1-2 | 1 point |
| 19/02/22 14:30 | 18/02/22 19:00 | VfB Stuttgart | VfL Bochum | 1-1 | 1 point |
| 19/02/22 14:30 | 18/02/22 19:00 | VfL Wolfsburg | 1899 Hoffenheim | 1-2 | 1 point |
| 19/02/22 14:30 | 18/02/22 19:00 | Arminia Bielefeld | 1. FC Union Berlin | 1-0 | 1 point |
| 19/02/22 17:30 | 18/02/22 19:00 | 1. FC Köln | Eintracht Frankfurt | 1-0 | 1 point |
| 20/02/22 14:30 | 18/02/22 19:00 | FC Bayern Munich | SpVgg Greuther Fürth | 4-1 | 1 point |
| 20/02/22 16:30 | 18/02/22 19:00 | Borussia Dortmund | Bor. Mönchengladbach | 6-0 | 1 point |
| 20/02/22 18:30 | 18/02/22 19:00 | Hertha BSC | RB Leipzig | 1-6 | 1 point |