Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 14/12/21 17:30 | 14/12/21 17:00 | VfB Stuttgart | FC Bayern Munich | 0-5 | 1 point |
| 14/12/21 19:30 | 14/12/21 17:00 | Arminia Bielefeld | VfL Bochum | 2-0 | 1 point |
| 14/12/21 19:30 | 14/12/21 17:00 | FSV Mainz 05 | Hertha BSC | 4-0 | 1 point |
| 14/12/21 19:30 | 14/12/21 17:00 | VfL Wolfsburg | 1. FC Köln | 2-3 | 1 point |
| 15/12/21 17:30 | 14/12/21 17:00 | Bor. Mönchengladbach | Eintracht Frankfurt | 2-3 | 1 point |
| 15/12/21 19:30 | 14/12/21 17:00 | FC Augsburg | RB Leipzig | 1-1 | 1 point |
| 15/12/21 19:30 | 14/12/21 17:00 | 1. FC Union Berlin | SC Freiburg | 0-0 | 1 point |
| 15/12/21 19:30 | 14/12/21 17:00 | Bayer 04 Leverkusen | 1899 Hoffenheim | 2-2 | 1 point |
| 15/12/21 19:30 | 14/12/21 17:00 | Borussia Dortmund | SpVgg Greuther Fürth | 3-0 | 1 point |