Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 10/12/21 19:30 | 10/12/21 19:00 | 1. FC Köln | FC Augsburg | 0-2 | 1 point |
| 11/12/21 14:30 | 10/12/21 19:00 | RB Leipzig | Bor. Mönchengladbach | 4-1 | 1 point |
| 11/12/21 14:30 | 10/12/21 19:00 | FC Bayern Munich | FSV Mainz 05 | 2-1 | 1 point |
| 11/12/21 14:30 | 10/12/21 19:00 | VfL Bochum | Borussia Dortmund | 1-1 | 1 point |
| 11/12/21 14:30 | 10/12/21 19:00 | Hertha BSC | Arminia Bielefeld | 2-0 | 1 point |
| 11/12/21 14:30 | 10/12/21 19:00 | SC Freiburg | 1899 Hoffenheim | 1-2 | 1 point |
| 11/12/21 17:30 | 10/12/21 19:00 | VfL Wolfsburg | VfB Stuttgart | 0-2 | 1 point |
| 12/12/21 14:30 | 10/12/21 19:00 | SpVgg Greuther Fürth | 1. FC Union Berlin | 1-0 | 1 point |
| 12/12/21 16:30 | 10/12/21 19:00 | Eintracht Frankfurt | Bayer 04 Leverkusen | 5-2 | 1 point |