Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 22/10/21 20:00 | 22/10/21 19:59 | Arsenal FC | Aston Villa | 3-1 | 2 - 4 points |
| 23/10/21 12:30 | 23/10/21 12:29 | Chelsea FC | Norwich City | 7-0 | 2 - 4 points |
| 23/10/21 15:00 | 23/10/21 14:59 | Crystal Palace | Newcastle United | 1-1 | 2 - 4 points |
| 23/10/21 15:00 | 23/10/21 14:59 | Everton FC | Watford FC | 2-5 | 2 - 4 points |
| 23/10/21 15:00 | 23/10/21 14:59 | Leeds United | Wolverhampton Wanderers | 1-1 | 2 - 4 points |
| 23/10/21 15:00 | 23/10/21 14:59 | Southampton FC | Burnley FC | 2-2 | 2 - 4 points |
| 23/10/21 17:30 | 23/10/21 17:29 | Brighton and Hove Albion | Manchester City | 1-4 | 2 - 4 points |
| 24/10/21 14:00 | 24/10/21 13:59 | Brentford FC | Leicester City | 1-2 | 2 - 4 points |
| 24/10/21 14:00 | 24/10/21 13:59 | West Ham United | Tottenham Hotspur | 1-0 | 2 - 4 points |
| 24/10/21 16:30 | 24/10/21 16:29 | Manchester United | Liverpool FC | 0-5 | 2 - 4 points |