Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 17/09/21 20:00 | 17/09/21 19:59 | Newcastle United | Leeds United | 1-1 | 2 - 4 points |
| 18/09/21 12:30 | 18/09/21 12:29 | Wolverhampton Wanderers | Brentford FC | 0-2 | 2 - 4 points |
| 18/09/21 15:00 | 18/09/21 14:59 | Burnley FC | Arsenal FC | 0-1 | 2 - 4 points |
| 18/09/21 15:00 | 18/09/21 14:59 | Liverpool FC | Crystal Palace | 3-0 | 2 - 4 points |
| 18/09/21 15:00 | 18/09/21 14:59 | Manchester City | Southampton FC | 0-0 | 2 - 4 points |
| 18/09/21 15:00 | 18/09/21 14:59 | Norwich City | Watford FC | 1-3 | 2 - 4 points |
| 18/09/21 17:30 | 18/09/21 17:29 | Aston Villa | Everton FC | 3-0 | 2 - 4 points |
| 19/09/21 14:00 | 19/09/21 13:59 | West Ham United | Manchester United | 1-2 | 2 - 4 points |
| 19/09/21 14:00 | 19/09/21 13:59 | Brighton and Hove Albion | Leicester City | 2-1 | 2 - 4 points |
| 19/09/21 16:30 | 19/09/21 16:29 | Tottenham Hotspur | Chelsea FC | 0-3 | 2 - 4 points |