Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 11/09/21 12:30 | 11/09/21 12:29 | Crystal Palace | Tottenham Hotspur | 3-0 | 2 - 4 points |
| 11/09/21 15:00 | 11/09/21 14:59 | Brentford FC | Brighton and Hove Albion | 0-1 | 2 - 4 points |
| 11/09/21 15:00 | 11/09/21 14:59 | Leicester City | Manchester City | 0-1 | 2 - 4 points |
| 11/09/21 15:00 | 11/09/21 14:59 | Manchester United | Newcastle United | 4-1 | 2 - 4 points |
| 11/09/21 15:00 | 11/09/21 14:59 | Southampton FC | West Ham United | 0-0 | 2 - 4 points |
| 11/09/21 15:00 | 11/09/21 14:59 | Arsenal FC | Norwich City | 1-0 | 2 - 4 points |
| 11/09/21 15:00 | 11/09/21 14:59 | Watford FC | Wolverhampton Wanderers | 0-2 | 2 - 4 points |
| 11/09/21 17:30 | 11/09/21 17:29 | Chelsea FC | Aston Villa | 3-0 | 2 - 4 points |
| 12/09/21 16:30 | 12/09/21 16:29 | Leeds United | Liverpool FC | 0-3 | 2 - 4 points |
| 13/09/21 20:00 | 13/09/21 19:59 | Everton FC | Burnley FC | 3-1 | 2 - 4 points |