Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 28/08/21 12:30 | 28/08/21 12:29 | Manchester City | Arsenal FC | 5-0 | 2 - 4 points |
| 28/08/21 15:00 | 28/08/21 14:59 | Newcastle United | Southampton FC | 2-2 | 2 - 4 points |
| 28/08/21 15:00 | 28/08/21 14:59 | Norwich City | Leicester City | 1-2 | 2 - 4 points |
| 28/08/21 15:00 | 28/08/21 14:59 | West Ham United | Crystal Palace | 2-2 | 2 - 4 points |
| 28/08/21 15:00 | 28/08/21 14:59 | Aston Villa | Brentford FC | 1-1 | 2 - 4 points |
| 28/08/21 15:00 | 28/08/21 14:59 | Brighton and Hove Albion | Everton FC | 0-2 | 2 - 4 points |
| 28/08/21 17:30 | 28/08/21 17:29 | Liverpool FC | Chelsea FC | 1-1 | 2 - 4 points |
| 29/08/21 14:00 | 29/08/21 13:59 | Tottenham Hotspur | Watford FC | 1-0 | 2 - 4 points |
| 29/08/21 14:00 | 29/08/21 13:59 | Burnley FC | Leeds United | 1-1 | 2 - 4 points |
| 29/08/21 16:30 | 29/08/21 16:29 | Wolverhampton Wanderers | Manchester United | 0-1 | 2 - 4 points |