Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 04/12/21 12:30 | 04/12/21 12:29 | West Ham United | Chelsea FC | 3-2 | 2 - 4 points |
| 04/12/21 15:00 | 04/12/21 14:59 | Newcastle United | Burnley FC | 1-0 | 2 - 4 points |
| 04/12/21 15:00 | 04/12/21 14:59 | Southampton FC | Brighton and Hove Albion | 1-1 | 2 - 4 points |
| 04/12/21 15:00 | 04/12/21 14:59 | Wolverhampton Wanderers | Liverpool FC | 0-1 | 2 - 4 points |
| 04/12/21 17:30 | 04/12/21 17:29 | Watford FC | Manchester City | 1-3 | 2 - 4 points |
| 05/12/21 14:00 | 05/12/21 13:59 | Leeds United | Brentford FC | 2-2 | 2 - 4 points |
| 05/12/21 14:00 | 05/12/21 13:59 | Manchester United | Crystal Palace | 1-0 | 2 - 4 points |
| 05/12/21 14:00 | 05/12/21 13:59 | Tottenham Hotspur | Norwich City | 3-0 | 2 - 4 points |
| 05/12/21 16:30 | 05/12/21 16:29 | Aston Villa | Leicester City | 2-1 | 2 - 4 points |
| 06/12/21 20:00 | 06/12/21 19:59 | Everton FC | Arsenal FC | 2-1 | 2 - 4 points |