Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 05/11/21 20:00 | 05/11/21 19:59 | Southampton FC | Aston Villa | 1-0 | 2 - 4 points |
| 06/11/21 12:30 | 06/11/21 12:29 | Manchester United | Manchester City | 0-2 | 2 - 4 points |
| 06/11/21 15:00 | 06/11/21 14:59 | Brentford FC | Norwich City | 1-2 | 2 - 4 points |
| 06/11/21 15:00 | 06/11/21 14:59 | Chelsea FC | Burnley FC | 1-1 | 2 - 4 points |
| 06/11/21 15:00 | 06/11/21 14:59 | Crystal Palace | Wolverhampton Wanderers | 2-0 | 2 - 4 points |
| 06/11/21 17:30 | 06/11/21 17:29 | Brighton and Hove Albion | Newcastle United | 1-1 | 2 - 4 points |
| 07/11/21 14:00 | 07/11/21 13:59 | Arsenal FC | Watford FC | 1-0 | 2 - 4 points |
| 07/11/21 14:00 | 07/11/21 13:59 | Everton FC | Tottenham Hotspur | 0-0 | 2 - 4 points |
| 07/11/21 14:00 | 07/11/21 13:59 | Leeds United | Leicester City | 1-1 | 2 - 4 points |
| 07/11/21 16:30 | 07/11/21 16:29 | West Ham United | Liverpool FC | 3-2 | 2 - 4 points |