| Date | Home | Away | Result |
|---|---|---|---|
| 04/11/22 20:00 | Reading FC | Preston North End | 1-2 |
| 05/11/22 12:30 | Sheffield United | Burnley FC | 5-2 |
| 05/11/22 15:00 | Stoke City | Birmingham City | 1-2 |
| 05/11/22 15:00 | FC Blackpool | Luton Town | 0-1 |
| 05/11/22 15:00 | Blackburn Rovers | Huddersfield Town | 1-0 |
| 05/11/22 15:00 | AFC Sunderland | Cardiff City | 0-1 |
| 05/11/22 15:00 | Watford FC | Coventry City | 0-1 |
| 05/11/22 15:00 | Middlesbrough FC | Bristol City | 1-1 |
| 05/11/22 15:00 | Rotherham United | Norwich City | 1-2 |
| 05/11/22 15:00 | Swansea City | Wigan Athletic | 2-2 |
| 05/11/22 15:00 | Queens Park Rangers | West Bromwich Albion | 0-1 |
| 05/11/22 15:00 | Millwall FC | Hull City A.F.C. | 0-0 |