| Date | Home | Away | Result |
|---|---|---|---|
| 07/10/22 20:00 | Queens Park Rangers | Reading FC | 2-1 |
| 08/10/22 15:00 | Norwich City | Preston North End | 2-3 |
| 08/10/22 15:00 | Millwall FC | Middlesbrough FC | 2-0 |
| 08/10/22 15:00 | West Bromwich Albion | Luton Town | 0-0 |
| 08/10/22 15:00 | Coventry City | Burnley FC | 0-1 |
| 08/10/22 15:00 | Swansea City | AFC Sunderland | 2-1 |
| 08/10/22 15:00 | Birmingham City | Bristol City | 3-0 |
| 08/10/22 15:00 | Stoke City | Sheffield United | 3-1 |
| 08/10/22 15:00 | Wigan Athletic | Cardiff City | 1-3 |
| 08/10/22 15:00 | Blackburn Rovers | Rotherham United | 3-0 |
| 08/10/22 15:00 | FC Blackpool | Watford FC | 3-1 |
| 09/10/22 12:00 | Huddersfield Town | Hull City A.F.C. | 2-0 |